Scientist III KCAS Bio-Philadelphia Lower Gwynedd, Pennsylvania
Generation of multifunctional, anti-tumor T cell responses and immune memory are critical for effective long-term control of tumor growth and clinical outcomes. We will present data generated by the IsoLight instrument and the single-cell secretome adaptive immune proteomic assay. The data from which can be used to assess the functional state of tumor-specific CD4 and CD8 T cells. This will be supported, in part, by case study data analyzing multifunctional T cell responses in patients undergoing immunotherapy for HPV-positive head and neck cancer.
Learning Objectives:
Discuss IsoLight methods to assess population level and single-cell level cytokine profiling of T cell responders to tumor-specific stimulation.
Gain a better understanding of the polyfunctional strength index (PSI) and how it is used to measure the potency of immune responses.
Gain insights into the use of single-cell proteomics to predict disease progression, treatment resistance, and therapeutic efficacy.
