Presentation will focus on best practices for pharmaceutical materials characterization (drug product and final dosage forms) informed by nonlinear optical imaging. Topics will include a critical assessment of commercially available and home-built instrumentation, interpretation of image contrast from nonlinear optical signals, pairing nonlinear optical imaging with Raman spectroscopy, X-ray microdiffraction, and IR absorption, and quantitative interpretation of nonlinear optical images. Applications include non-contact analysis during accelerated stability testing and crystal form screening.
Learning Objectives:
Understand key differences between linear and nonlinear light/matter interactions.
Build appreciation of key practical design considerations for nonlinear optical microscopy instrumentation.
Gain familiarity with hyphenated methods, in which nonlinear optical imaging is coupled with complementary spectrochemical analyses for synergistic integrated characterization
Understand image analysis options and algorithms for quantitative measurements.
Identify measurement challenges with potential to benefit from nonlinear optical imaging.
