Assistant Professor University of Florida Orlando, Florida
Three-dimensional (3D) cell culture models present physiologically relevant cellular microenvironment and offer great promise for assessing drug disposition and pharmacokinetics (PKs) that influence drug safety and efficacy from an early stage of drug development. Currently, there are numerous different types of 3D culture systems, from simple spheroids to more complicated organoids and organs-on-chips, and from single-cell type static 3D models to cell co-culture 3D models equipped with microfluidic flow control as well as hybrid 3D systems that combine 2D culture with biomedical microelectromechanical systems. This presentation reviews the current application and challenges of 3D culture systems in drug PKs and safety assessment.
Learning Objectives:
Introduce static and dynamic microphysiological systems to assess ADME-Tox at early stages of development
Get familiarized with different live models for toxicity and PK evaluation
Learn about novel 3D intestine models for assessing drug permeability and intestinal metabolism
Integrating organoids/organ-on-chip models with PBPK modeling for translational research focusing special populations not well represented in pre-approval clinical trials
